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The action on kidneys appears to be directly through the effects also on renin-secreting cells of the juxta-glomerular apparatus, whose stimulation may lead to increased natriuresis and reduce hyperfiltration, and indirectly by the reduction of angiotensin II levels, the increase in nitric oxide with consequently endothelial vasodilation and the improvement of risk factors of kidney disease (hyperglycemia, hypertension, obesity) (20)

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A fluorescence microscope (Nikon, Tokyo, Japan) and a Leica DM2000 scanner (Leica Biosystems, Wetzlar, Germany) were used for observation and analysis

And so just as theres not one type of diabetes or one cause for high blood pressure, theres not one type of obesity